Griffin, a former light heavyweight champion and winner of The Ultimate Fighter, withdrew from the co-main event matchup late Monday after suffering a shoulder injury. It is not yet known when he’ll be able to return.
Following back-to-back wins over Brad Morris and Tim Boetsch to begin his UFC career, Brilz (18-2-1) most-recently rebounded from a loss to Eliot Marshall with a unanimous decision over Eric Schafer at UFC on Versus 1 in March.
Nogueira (18-3) made his UFC debut in November, jumping into contention with a first-round “Knockout of the Night” of Luiz Cane for his sixth-straight win.
UFC 114 is headlined by a grudge match between former 205-pound champs Quinton “Rampage” Jackson and Rashad Evans, and also includes Michael Bisping vs. Dan Miller, Todd Duffee vs. Mike Russow, and John Hathaway vs. Diego Sanchez.
Pictured: Jason Brilz